Solute carrier family 22 member 17 ( Q9D9E0)

Uniprot ID Q9D9E0
Protein Name Solute carrier family 22 member 17
Gene Name Slc22a17
Species Mus musculus (Mouse)
Signal peptide(a) N Secretome P(b)
Function Cell surface receptor for LCN2 (24p3) that plays a key role in iron homeostasis and transport. Able to bind iron-bound LCN2 (holo-24p3), followed by internalization of holo-24p3 and release of iron, thereby increasing intracellular iron concentration and leading to inhibition of apoptosis. Also binds iron-free LCN2 (apo-24p3), followed by internalization of apo-24p3 and its association with an intracellular siderophore, leading to iron chelation and iron transfer to the extracellular medium, thereby reducing intracellular iron concentration and resulting in apoptosis. .
GO - Molecular function
  • transmembrane signaling receptor activity : IMP:UniProtKB
  • transmembrane transporter activity : TAS:Reactome
GO - Biological process
  • iron ion homeostasis : IEA:UniProtKB-KW
  • siderophore transport : IMP:UniProtKB
(a) The Signal peptide D-score cutoff for "YES"(having signal peptide) is 0.45.
(b) Non-classically secreted proteins should obtain an NN-score(Neural Networks score) exceeding the normal threshold of 0.5, but not at the same time be predicted to contain a signal peptide.